2-(aminoaryl) indoles and indolines as topical antiinflammatory

Details 2-(aminoaryl) indoles and indolines as topical antiinflammatory 2-(aminoaryl) indoles and indolines as topical antiinflammatory

1989-07-03

1992-11-24

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548469, 548491, 548494, 548503, C07D20904, A61K 3134

Patent

active

051661705

ABSTRACT:
There are disclosed various compounds depicted by the general formula, ##STR1## where the parameters X, Y, R.sub.1, R.sub.2, and R.sub.3 are as defined in the specification. These compounds are disclosed as topical antiinflammatory agents useful for the treatment of various skin disorders including exogenous dermatitis, endogenous dermatitis, dermatitis of unknown etiology and other cutaneous disorders with an inflammatory component.

REFERENCES:
patent: 3642778 (1972-02-01), Helsley
patent: 3642779 (1972-02-01), Duncan
patent: 3732236 (1973-05-01), Wu
patent: 3941806 (1976-03-01), Welstead, Jr. et al.
patent: 4448784 (1984-05-01), Glamowski et al.
Chemical Abstracts Service: Abstracts Numbers: CA88:89465, 1978; CA86:74390, 1977; CA105:133702, 1986.
Chemical Abstracts Service 109:22954K, 1988.
Chemical Abstracts Service 94:65469V, 1981.
Leuchs, Chem Abstr., Vol. 29, 158 (1935).
Duncan, J. Heterocyclic Chem., Vol. 10, 65-70 (1973).
Gribble, Synthesis, 859-860 (1977).

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