Method for inhibing adhesion of white blood cells to endothelial

Details Method for inhibing adhesion of white blood cells to endothelial Method for inhibing adhesion of white blood cells to endothelial

1991-05-14

1992-11-24

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3702, A61K 3764

Patent

active

051661330

ABSTRACT:
Proteins are described that affect adhesion of white blood cells (WBCs) to endothelial cells (ECs). The proteins include inter-.alpha.-trypsin inhibitor, .alpha..sub.1 -M, and HI-30. When administered in therapeutically effective amounts, these proteins can alter adhesion between WBCs and ECs to ultimately prevent inflammatory-type diseases.

REFERENCES:
patent: 4485100 (1984-11-01), Hochstrasser et al.
Akerstrom et al., 1990, TIBS, 15:240-243.
Diarra-Mehrpour, et al., 1989, Eur. J. Biochem. 179:147-154.
Goodman et al, "The Phamacological Basic of Therapy" (7th Edition) MacMillan Publishing Co., pp. 675-676.

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