Anti-inflammatory and analgesig thiophene acetic acid derivative

Details Anti-inflammatory and analgesig thiophene acetic acid derivative Anti-inflammatory and analgesig thiophene acetic acid derivative

1986-03-06

1988-01-12

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514278, 514409, 549 43, 548407, 546 15, 544146, 544375, A61K 3138, C07D40112, C07D41312, C07D33378

Patent

active

047192240

ABSTRACT:
Novel optically active isomers or racemic mixtures of thiophene acetic acid derivatives of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, Y is selected from the group consisting of --OR.sub.2 and ##STR2## R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and ##STR3## n is an integer from 2 to 5, X' and X" are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms or taken together with the nitrogen atom form an optionally unsaturated heterocycle of 5 to 6 ring members, R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable salts with acids and bases having a good analgesic and anti-inflammatory activity and inhibition of 5-lipoxygenase and cyclooxygenase, a process and intermediates for their preparation.

REFERENCES:
Shen et al, The Development of Antiasthma Drug, Part III, ed, Butterworth Publishers, Kent, England, 1980.
Stanetty, CA vol. 95, 1981, 95:61895d.

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