Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressan

Details Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressan Hexahydropyrrolo(2,1-A)isoquinoline derivatives as antidepressan

1986-03-14

1988-01-12

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 94, A61K 3147, C07D45100

Patent

active

047192160

ABSTRACT:
Novel compounds are disclosed, which are derivatives of 1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]-isoquinolines, represented by general formula (I): ##STR1## as well as pharmaceutical compositions and methods for the treatment of depression in warm-blooded animals, e.g., man. Novel intermediates are also part of the invention.

REFERENCES:
patent: 3502679 (1970-03-01), Houlihan et al.
patent: 3635984 (1972-01-01), Houlihan et al.
patent: 3892752 (1975-07-01), Houlihan et al.
"Use of the Butaclamol Template in a Search for Antipsychotic Agents with Lessened Side Effects", by Michael J. Kukla et al., in The Journal of Medicinal Chemistry, (1979) vol. 22 pp. 401-406.
Ronald C. Griffith et al., Journal of Medicinal Chemistry, vol. 2 pp. 995-1003 (Aug. 1984).
"Synthesis and Pharmacological Evaluation of Some Pyrrolo [2,1-a] Isoquinolines" Cesare Casagrande et al., Jul. 1968, pp. 765-770, vol. 11.
"Intramolecular Amidoalkylations at Carbon Synthesis of Heterocyclic Amines", M. Winn et al., vol. 33, No. 10, Oct. 1968, pp. 3779-3783.
Abstract of European Patent No. 107,825-A.

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