Anti-cancer composition for delivering 5-fluorouracil

Details Anti-cancer composition for delivering 5-fluorouracil Anti-cancer composition for delivering 5-fluorouracil

1986-08-28

1988-01-12

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31505

Patent

active

047192135

ABSTRACT:
An anti-cancer composition for delivering a 5-fluorouracil to cancer tissues in a warm-blooded animal, wherein the cancer is a cancer sensitive to 5-fluorouracil. The composition comprises uracil or a pharmaceutically acceptable salt thereof, and a 5-fluorouracil pro drug selected from the group consisting of 1, 3-bis (2-tetrahydrofuryl)-5-fluorouracil and 3-(2-tetrahydrofuryl)-5-fluorouracil in a small amount of about 0.1 to less than 0.1 mole per mole of uracil or salt thereof.

REFERENCES:
patent: 4328229 (1982-05-01), Fujii et al.
patent: 4371535 (1983-02-01), Unemi et al.
patent: 4481203 (1984-11-01), Fujii et al.
patent: 4507301 (1985-03-01), Fujii et al.

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