Diphosphonic acid derivatives, processes for the preparation the

Details Diphosphonic acid derivatives, processes for the preparation the Diphosphonic acid derivatives, processes for the preparation the

1986-11-12

1988-01-12

Evans, J. E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

2605025C, 514 89, 514 94, 514 95, 546 22, 548112, 549 6, 558158, 558159, 558161, 558163, C07F 938, A61K 31045, A61K 3113, A61K 31185

Patent

active

047192038

ABSTRACT:
Diphosphonate compounds, processes for their preparation and pharmaceutical compositions containing them and being useful for treating calcium metabolism disorders. The diphosphonates are of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen, acyl or alkyl which can be substituted by aryl, R.sub.3 and R.sub.4 are hydrogen or alkyl or R.sub.3 and R.sub.4 together represent lower alkylene, R.sub.5 is a hydrogen atom or alkyl, X is a valency bond or alkylene, Y is a valency bond, alkylene or substituted alkylene, Z is hydrogen, hydroxyl or amino group optionally substituted by alkyl and n is 1, 2 or 3; and including the pharmacologically acceptable salts thereof.

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patent: 4304734 (1981-12-01), Jary et al.
patent: 4407761 (1983-10-01), Blum et al.
patent: 4624947 (1986-11-01), Blum et al.

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