Process for the production of 4-halo-3-hydroxybutyronitrile with

Details Process for the production of 4-halo-3-hydroxybutyronitrile with Process for the production of 4-halo-3-hydroxybutyronitrile with

1990-07-20

1992-11-24

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435 41, 435155, 435157, 435195, 435822, 435843, C12P 100, C12P 1300, C12P 702, C12P 704, C12N 914

Patent

active

051660610

ABSTRACT:
A process for the production of a 4-halo-3-hydroxybutyronitrile which comprises reacting a 1,3-dihalo-2-propanol with a dehalogenating enzyme originating from a Corynebacterium or a Microbacterium in the presence of an alkali cyanide to thereby convert the 1,3-dihalo-2-propanol into the 4-halo-3-hydroyxbutyronitrile and collecting the product thus formed is disclosed. According to this process, a 4-halo-3-hydroxybutyronitrile which is highly useful in the syntheses of various medicines and physiologically active substances can be easily and efficiently produced from an inexpensive starting material.

REFERENCES:
patent: 4943528 (1990-07-01), Nakamura et al.
Janssen et al. (1987) Appl. Environ. Microbiol. 53(3), 561-566 in Chem. Abstr., 106(18), p. 328, Abst # 143413e.
Janssen et al. (1988) Eur. J. Biochem., 171, 67-72.
Hardman et al. (1981) J. Gen. Microbiol., 123, 117-128.
Bernhard (1968) "The Structure and Function of Enzymes", pp. 177-184, Benjamin, Menlo Park.

Affiliated with

Also associated with

Rating

Process for the production of 4-halo-3-hydroxybutyronitrile with does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of 4-halo-3-hydroxybutyronitrile with, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of 4-halo-3-hydroxybutyronitrile with will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-921218