Microbiological preparation of 9-alpha-hydroxy-17-keto steroids

Details Microbiological preparation of 9-alpha-hydroxy-17-keto steroids Microbiological preparation of 9-alpha-hydroxy-17-keto steroids

Filed on

1991-07-15

Date issued

1992-11-24

Examiner

Raymond, Richard L.

Patent Class

Chemistry: molecular biology and microbiology

SubClass

Micro-organism, tissue cell culture or enzyme using process...

SubSubClass

Preparing compound containing a...

Other Related Categories

4352531, 435863, C12P 3316

Type

Patent

Status

active

Patent number

051660555

Description

ABSTRACT:
9.alpha.-hydroxy-17-keto steroids are prepared by fermenting steroids having a C-17-side chain of 5-10 carbon atoms inclusive, with the novel Mycobacterium species CBS 482.86.
Starting from various substrates containing a 5-10 C carbon chain on C-17, 9.alpha.-hydroxyandrost-4-ene-3,17-dione, 7.alpha.,9.alpha.,12.alpha.-trihydroxyandrost-4-ene-3,17-dione or 9.alpha.-hydroxyandrost-4,11-diene-3,17-dione is obtained in high yield.
The resulting compounds are useful intermediates in the synthesis of therapeutically important steroids, particularly corticosteroids.

REFERENCES:
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patent: 3759791 (1973-09-01), Marsheck et al.
patent: 4035236 (1977-07-01), Wovcha
patent: 4226936 (1980-10-01), Wovcha et al.
patent: 4320195 (1982-03-01), Hill et al.
patent: 4345029 (1982-08-01), Wovcha et al.
patent: 4345033 (1982-08-01), Wovcha et al.
patent: 4358538 (1982-11-01), Wovcha et al.
patent: 4397947 (1983-08-01), Marsheck et al.
J. Org. Chem., vol. 44, No. 9, 1979, pp. 1582-1584.
J. Am. Chem. Soc., 80, 1958, p. 6148.

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