Process of using anti-inflammatory furanones as selective calciu

Details Process of using anti-inflammatory furanones as selective calciu Process of using anti-inflammatory furanones as selective calciu

1991-08-30

1994-12-27

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549295, A61K 3134

Patent

active

053766768

ABSTRACT:
4-(C.sub.10 -C.sub.20)alkyl-2(5H)-furanone compounds are selective calcium channel inhibitors and useful for treatment of diseases such as hypertension, angina, cardiac arrythmia, pulmonary hypertension, aortic insufficiency, Raynand's disease, migraine headaches, deficiency of platelet function, atherosclerosis, ischemia, reprofusion injury, bronchial asthma, esophageal spasm, dysmenorhea, allergic contact dermatitis, acute inflammatory response, glaucoma and as potentiators of chemotherapeutic agents in the treatment of tumors.

REFERENCES:
patent: 2359096 (1944-09-01), Elderfield
patent: 2359208 (1944-09-01), Elderfield
patent: 4447445 (1984-05-01), Jacobs
patent: 4786651 (1988-11-01), Wheeler
patent: 4789749 (1988-12-01), Jacobs et al.
patent: 4855320 (1989-08-01), Chatterjee et al.
patent: 4874782 (1989-10-01), Bonjouklian et al.
patent: 4916241 (1990-04-01), Hayward et al.
patent: 4935530 (1990-06-01), Lee
patent: 5013850 (1991-05-01), Lee
patent: 5037811 (1991-08-01), Lee
patent: 5043457 (1991-08-01), Lee
patent: 5045564 (1991-09-01), Lee
Bonjuklian, et al., Chemical Abstracts, vol. 106, 156260c, p. 670 (1987).
Reynolds, et al, J. Am. Chem. Soc., 110, pp. 5172-5177 (1988).
Tocanne et al., Chemical Abstracts 69, 76581k, p. 7146 (1968).
Deems, et al, Biochimica et Biophysica Acta, 917 pp. 258-268 (1987).
Scheuer et al., Journal of the American Chemical Society 100:1 p. 307 (Jan. 4, 1978).
Graziano, et al., Chemical Abstracts 107, (1987), 236559t.
Roll et al., Org. Chem. 1988, 53 3276-8.
Negishi et al., J. Org. Chem. 45, pp. 5223-5225, (1980).
E. D. de Silva et al., "Tetrahedron Letters", 21:1611-1614 (1980).
Nakagawa et al., "Aldose reductase inhibitor from Palaun sponges" Chem. Abstract 106: 96126b (1986).
Tanaka, et al., The Chemical Society of Japan, Chemistry Letters, pp. 633-636 (1983).
Tanis, et al., Tetrahedron Letters, vol. 25, No. 40, pp. 4451-4454 (1984)-Furans in Synthesis 4. Silyl Furans as Butenolide Equivalents.
Graziano, et al, "Photosensitized Oxidation of Furans, Part 12, Solvent Effects In Thermal Rearrangement Of The 2,5-Peroxides Of 2,5-Unsubstituted Furans", J. Chem. Soc., Perkin Trans, 1, (8), 1833-9, Apr. 19, 1989.
David Nettleton, et al, Inflammation Research Association, Fifth International Conference Poster Session, Phospholipase A.sub.2 Inhibition by Dihydrofuranones, Sep. 23-27, 1990.

Affiliated with

Also associated with

Rating

Process of using anti-inflammatory furanones as selective calciu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process of using anti-inflammatory furanones as selective calciu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of using anti-inflammatory furanones as selective calciu will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-920006