Dopamine-beta-hydroxylase inhibitors

Details Dopamine-beta-hydroxylase inhibitors Dopamine-beta-hydroxylase inhibitors

1987-03-24

1988-08-09

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514398, 548321, 548337, A61K 31415, C07D23390

Patent

active

047628502

ABSTRACT:
Potent dopamine-.beta.-hydroxylase inhibitors having the Formula ##STR1## that are useful to inhibit dopamine-.beta.-hydroxylase activity, pharmaceutical compositions including these inhibitors, and methods of using these inhibitors to inhibit dopamine-.beta.-hydroxylase activity in mammals. Also disclosed are novel intermediates useful in preparing the presently invented inhibitors.

REFERENCES:
patent: 4532331 (1985-06-01), Frazee et al.
Chemical Abstracts, 98:53763f (1983), [Belgodere, E. et al., J. Heterocycl. Chem. 1982, 19, 561].
Chemical Abstracts, 101:55015t (1984), [Belgodere, E., et al., Heterocycles, 1984, 22, 807].
Chemical Abstracts, 91:184927r (1979), [UK Appl. 2, 002, 917, Larossa, 2/28/79].
Chemical Abstracts, 100:85629t (1984), [Belgodere, E. et al., Heterocycles 1983, 20, 2019].
Blicke, F., in Thiophene and Its Derivatives by H. D. Hartough, Interscience, New York, 1952, p. 29.
Chemical Abstracts, 102:132034y (1985) [Eur. Pat. Appl. EP 125,033, Frazee et al., 11/14/84].

Affiliated with

Also associated with

Rating

Dopamine-beta-hydroxylase inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Dopamine-beta-hydroxylase inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Dopamine-beta-hydroxylase inhibitors will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-918869