Amino disulfide thiol exchange products

Details Amino disulfide thiol exchange products Amino disulfide thiol exchange products

1985-09-23

1989-09-12

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548422, C07D48714, A61K 3140

Patent

active

048661805

ABSTRACT:
This invention refers to 7-amino mitosane analogs (mitomycin C) in which the 7-amino group bears an organic substituent incorporating a disulfide group and to a novel thiol exchange process for producing these compounds. The compounds are inhibitors of experimental animal tumors.

REFERENCES:
patent: 3332944 (1967-07-01), Cosulich et al.
patent: 3420846 (1969-01-01), Matsui et al.
patent: 3450705 (1969-06-01), Matsui et al.
patent: 3514452 (1970-05-01), Matsui et al.
patent: 3660578 (1972-05-01), Hata et al.
patent: 4231936 (1980-11-01), Nakano et al.
patent: 4268676 (1981-05-01), Remers
patent: 4691024 (1987-09-01), Shirahata et al.
March, Advanced Organic Chemistry, 2nd ed. (1977), p. 1115.
J. Amer. Chem. Soc. 84, 3185-3187 (1962), J. S. Webb et al.
The Journal of Antibiotics, XXI, 189-198 (1968), Matsui et al.
J. Med. Chem. 14, 103-109 (1971), Kinoshita et al.
J. Med. Chem. 24, 975-981 (1981), Iyengar et al.
Physicians' Desk Reference, 35th Edition, 1981, pp. 717-718.
Iyengar et al.--Abstracts of Papers, 183rd Annual Meeting of the American Chemical Society, Mar. 1982, No. MEDI 72.
C. A. Claridge et al.--Abst. of the Annual Meeting of Amer. Soc. for Microbiology, 1982, Abs. 028.
J. Med. Chem., 1983, 26, 16-20, Iyengar et al.
Iyengar et al., Abstracts of Papers, 185th Annual Meeting of the American Chemical Society, Mar. 1983, No. MEDI 82.
Farmdoc No. 56227 D/31.
American Association of Cancer Research Poster Material presented May 25, 1983 in San Diego, Calif.
Shirahata et al., J. Am. Chem. Soc., 1983, 105, 7199-7200.

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