Method and compositions for topical application to the skin for

Details Method and compositions for topical application to the skin for Method and compositions for topical application to the skin for

1993-01-13

1994-12-27

Ore, Dale R.

Drug, bio-affecting and body treating compositions

Topical sun or radiation screening, or tanning preparations

424 60, 514474, A61K 742, A61K 744, A61K 3134

Patent

active

053763610

ABSTRACT:
A method for the prevention and/or treatment of radiation-induced skin damage, particularly ultraviolet-induced skin burn (e.g., sunburn), in which a tocotrienol, a derivative thereof or a vitamin E preparation enriched with tocotrienol or a tocotrienol derivative, is topically applied to the exposed or affected skin areas. A fat-soluble fatty acid ester of ascorbic acid such as palmityl ascorbate is preferably applied with the tocotrienol in association with a dermatologically acceptable carrier. Tocotrienol augments the efficacy of sunscreens containing compounds that reduce penetration of or absorb ultraviolet radiation.

REFERENCES:
patent: 4695452 (1987-09-01), Gannis et al.
patent: 4938969 (1990-07-01), Schinitsky et al.
patent: 4975272 (1990-12-01), Voyt
patent: 4983382 (1991-01-01), Wilmott et al.
Encyclopedia of Chem. Technology, 3rd ed. vol. 20, pp. 762-763, 1982.
Grant & Hackh's Chemical Dictionary, 5th ed., pp. 529-530, 1987.

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