Peptide compounds having therapeutic activity

Details Peptide compounds having therapeutic activity Peptide compounds having therapeutic activity

1994-08-22

1996-03-26

Warden, Jill

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

A61K 3800, C07K 700, C07K 706

Patent

active

055021646

ABSTRACT:
Compounds of formula I, ##STR1## wherein M is Met, DMet, MeMet, MetO, Ahx, DAhx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala or Lys, G is Gly, DAla, Pro, Ala, .beta.Ala or Sar; W is Trp, MeTrp, Ala or Nal; X is Met, MeMet, MetO, Ahx, MeAhx, Leu, MeLeu, Pro, Ile, MeIle, Ala, Phe, Lys or Lys(R.sup.8); J is Asp, DAsp, MeAsp, Asp(OBn), Ala or MeDAsp; F.sup.1 is (S)--NH, (R)--NH, (S)--R.sup.1 N or (R)--R.sup.2 N; F.sup.2 is H, Cl, I, Br, F, NO.sub.2, NH.sub.2, R.sup.3 or OR.sup.4 ; Z is NH.sub.2, NHR.sup.5 or NR.sup.5 R.sup.6 ; R.sup.1, R.sup.2, R.sup.3, R.sup.5 and R.sup.6 are alkyl C.sub.1-6 ; R.sup.4 is H or alkyl C.sub.1-4 ; R.sup. is OH or OSO.sub.3 H; and pharmaceutically acceptable derivatives thereof; are useful as therapeutic agents, in particular in the inhibition of feeding.

REFERENCES:
patent: 4490364 (1984-12-01), Rivier et al.
patent: 5013722 (1991-05-01), Danho et al.
patent: 5086042 (1992-02-01), Rosamond
American Journal of Physiology, vol. 258, 1990, Chun Wel Lin et al. "A71378: a CCK agonist with high potency and selectivity for CCK-A receptors" (Abstract, pG649, col. 2, 1. 1-13).
Journal of Medicinal Chemistry vol. 35, No. 16, Aug. 1992, Mark W. Holladay et al. "Synthesis and Biological Activity of CCK Heptapeptide Analogues . . . " pp. 2919-2928.

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