Method of inhibiting leukemias and sarcomas in a mammalian host

Details Method of inhibiting leukemias and sarcomas in a mammalian host Method of inhibiting leukemias and sarcomas in a mammalian host

1987-01-06

1989-09-12

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 546 65, A61K 3147

Patent

active

048660710

ABSTRACT:
A new antineoplastic substance denominated "pancratistatin". Methods of isolating natural and synthetic pancratistatin and 7-deoxynarciclasine and the pharmaceutically acceptable derivatives thereof to make a pharmaceutical preparation therefrom and methods for treating a host afflicted with a neoplasm with said preparations.

REFERENCES:
patent: 3588993 (1971-06-01), Okamoto et al.
Keck et al., "Synthetic Studies on Lycoricidine", Tetra. Let., vol. 22, No. 28, pp. 2615-2618 (1981).
Mondon et al., "Zur Kenntnis des Narciclasins", Chem. Ber., 108, pp. 445-463 (1975).
Pettit et al., "Isolation and Structure of Pancratistan", Journ. Chem. Soc. Chem. Comm., pp. 1693-1694 (1984).
Piozzi, "Narciclasine and Narciprimine", Tetra., vol. 24, pp. 1119-1131 (1968).
Keek et al., Tetrahedron Letters, vol. (22), No. 28, pp. 2615-2618 (1981).
Piozzi et al., Tetrahedron, vol. 24, pp. 1119-1131 (1968).

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