Substance 4181-2 and its derivatives having anti-leukemia activi

Details Substance 4181-2 and its derivatives having anti-leukemia activi Substance 4181-2 and its derivatives having anti-leukemia activi

1988-10-03

1989-09-12

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514908, 546 36, A61K 3133, C07D49114, C07D491147

Patent

active

048660698

ABSTRACT:
Disclosed are a compound of the general formula ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom, an alkyl group or an acyl group, process for the production thereof and use thereof. The compounds have an antitumor activity, and those wherein both of R.sub.1 and R.sub.2 represent a hydrogen atom or an acyl group are novel compounds.

REFERENCES:
patent: 4814449 (1989-03-01), Chang-qing et al.
Omura et al., CA106-47255 (1987), "Structure of Cervinomycin; a Novel Antianaerobic Antibiotic".
Nakajawa et al., CA106-814327 (1987), "Enhanced Anti-microbial Activity of Acetyl Derivatives of Cervinomycin".
Nakajawa et al., CA107-217314t(1987), "Structure of Cervinomycin, a Novel Xanthone Antibiotic Active Against Anaeroben and Mycoplasma".
The Journal of Antibiotics, vol. XXXV, No. 6 (1982), pp. 645-652.
Proceedings of 106th Congress of Japanes Phamacological Society held on 4/2-4/1986, p. 207,45-10-3, by Nakagawa et al., p. 489, 3E 10-3, by Shimizu et al.
Omura et al., J.A.C.S. 108(1986) pp. 6088-6089.
Omura et al., The Journal of Antibiotics, vol. XL, No. 3, (1987), pp. 301-308.

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