Derivatives having expectorant activity, the procedure for their

Details Derivatives having expectorant activity, the procedure for their Derivatives having expectorant activity, the procedure for their

1983-09-28

1985-07-09

Killos, Paul J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

560 61, C07C 6976

Patent

active

045283931

ABSTRACT:
New esters of N-(2-amino-3,5-dibromobenzyl)trans-4-aminocyclohexanol, along with certain phenolic derivatives, present interesting expectorant activity, associated with an acute toxicity which is very low. They are, therefore, useful as active principles in pharmaceutical compositions, for oral, topical, injection and rectal use, and are especially indicated for the treatment of bronchial affections.

REFERENCES:
Curti, P. C., Pneumonologie, 147(1), 62-74, 1972.
Seydel, J. K. et al., Biochem. Pharmacol., 25(21), 2357-64, 1976.
Eckert, H. et al., Lung, 161(4), 213-18, 1983.
Wauer, R., Symp. Giovanni Lorenzini Found., 16(Pulm. Surfactant Syst.), 173-88, 1983.

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