Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.su

Details Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.su Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.su

1984-04-16

1985-07-09

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544 60, 544133, 544367, 544124, 544364, 544360, 544134, 544135, 546193, 546277, 546256, 548135, C07D41714, C07D41914, C07D41712, C07D41912

Patent

active

045283788

ABSTRACT:
Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepared by ring closure of a substituted ethanediimidamide of the formula ##STR2##

REFERENCES:
patent: 4374248 (1983-02-01), Crenshaw et al.
patent: 4411899 (1983-10-01), Baldwin et al.
patent: 4413129 (1983-11-01), Uchikuga et al.
patent: 4413130 (1983-11-01), White
Weinstock et al. in "Advances in Heterocyclic Chemistry" (Editors Katritzky and Boulton), vol. 9 (Academic Press) (1968), pp. 107-163.

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