Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.su

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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548135, 546256, 546270, 546277, 544 60, 544134, 544124, 544367, 2602455, 514342, 514362, 514222, 514212, 514333, 514326, 514255, C07D41710

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045283770

ABSTRACT:
Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepared by ring closure of a substituted ethanediimidamide of the formula ##STR2## .

REFERENCES:
patent: 4374248 (1983-02-01), Crenshaw et al.
patent: 4411899 (1983-10-01), Baldwin et al.
patent: 4413129 (1983-11-01), Uchikuga et al.
patent: 4413130 (1983-11-01), White
Komin et al., J. Het. Chem. 13, 13-22, (1976).
Weinstock et al., Advances in Heterocyclic Chem., vol. 9, N.Y., 1978, pp. _107-163.

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