Process for the production of cyclopropanenitrile derivatives

Details Process for the production of cyclopropanenitrile derivatives Process for the production of cyclopropanenitrile derivatives

1991-12-13

1992-10-27

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

558384, C07C25300, C07C25546

Patent

active

051591006

ABSTRACT:
A process for the production of cyclopropanenitrile derivatives. A diol of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are the same or different and each is a hydrogen atom, a C.sub.1 -C.sub.6 alkyl group, branched or unbranched, or a C.sub.1 -C.sub.6 alkenyl group, branched or unbranched, or wherein R.sub.1 and R.sub.2 together is a C.sub.4 -C.sub.6 cycloalkyl ring, is converted with thionyl chloride to a compound of the formula: ##STR2## The latter compound is then oxidized to a compound of the formula: ##STR3## The formula IV compound is converted with a cyano compound to the end product of the formula: ##STR4##

REFERENCES:
patent: 4203918 (1980-05-01), Brown
patent: 4217300 (1980-08-01), Lantzsch
patent: 4401601 (1983-08-01), Martel et al.
Nelson et al., J. Am. Chem. Soc., vol. 79, (1957), pp. 3467 to 3469.
Harnden, M. R., and Jarvest, R. L., Tetrahedron Letters, vol. 26, (1985), pp. 4265 to 4268.

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