Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1991-06-18
1992-10-27
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
514821, 514921, A61K 31195
Patent
active
051589788
ABSTRACT:
A method for the treatment of patients with acute cardiovascular compromise by administering a therapeutically effective amount of thyroid hormones. Methods of administration are included.
REFERENCES:
patent: 2803654 (1957-08-01), Anthony et al.
patent: 3109024 (1963-10-01), Meltzer et al.
patent: 4470962 (1984-09-01), Keith et al.
patent: 4666441 (1987-05-01), Andriola et al.
patent: 4818540 (1989-04-01), Chien et al.
patent: 4863970 (1989-09-01), Patel et al.
Gay, R. et al. Effects of L-Thyroxine in Rats with Chronic Heart Failure After Myocardial Infarction Am. J. Physiol. 253:H341-6 (1987).
Kranz, D. et al., The influence of hyperthyroidism & hypothyroidism on the wound healing of experimental myocardial infection in the rat Exp. Path. Bd. 12: 129-136 (1976).
Siverberg et al., Cardiology Series 5(2):6-26 (1982).
Novitsky et al., "Triiodothyronine Therapy in the Cardiac Transplant Recipient", Trans. Proc., 20:65-68 (1988).
Novitsky et al., "Ionotropic Effect of Triiodothyronine (T.sub.3) in Low Cardiac Output Following Cardioplegic Arrest and Cardiopulmonary Bypass: an Initial Experience in Patients Undergoing Open Heart Surgery", Eur. J. Cardiothorac. Surg., 3:140-145 (1989).
Novitsky et al., "Improved Cardiac Allograft Function Following Triiodothyronine Therapy to Both Donor and Recipient", Transplantation, 49:311-316 (1990).
Novitsky et al., "Triiodothyronine as an Inotropic Agent After Open Heart Surgery", J. Thorac. Cardiovasc. Surg., 98:972-978 (1989).
Novitsky et al., "Effect of Triiodothyronine (T.sub.3) on Myocardial High Energy Phosphates and Lactate After Ischemia and Cardiopulmonary Bypass", J. Thorac. Cardiovasc. Surg., 96:600-607 (1988).
Koga et al., "Primary Hypothyroidism in Severe Chronic Heart Failure", Jpn. J. Med., 27:42-48 (1988).
Meyer et al., "Treatment of Dopamine-Dependent Shock With Triiodothyronine: Preliminary Results", Deutsch Med. Wochenschr., 104:1711-1714 (1979). (Medline Abstact from the German article and the German article: Behandlung des dopaminab hangigen Schocks mit Tijodthyronin).
Meyer et al., "Treatment of Dopamine Dependent Schock With Triiodothyronine-Preliminary Report", Intensivmedizin, 17:148-152 (1980) (Medline Abstract from the German article and the German article: Behandlung des dopaminabhangigen Schocks mit Trijodthyronin--ein Vorlaufiger Bericht).
Hesch et al., "Treatment of Dopamine-Dependent Schock with Triiodothyronine", Endocr. Res. Commun., 8:229-237 (1981).
Moley et al., "Hypothyroidism Abolishes the Hyperdynamic Phase and Increases Susceptibility to Sepsis", J. Surg. Res., 36:265-273 (1984).
Novitsky et al., "Inotropic Effect of Triiodothyronine Following Myocardial Ischemia and Cardiopulmonary Bypass: An Experimental Study in Pigs", Ann. Thorac. Surg., 45:50-55 (1988).
British National Formulary No. 16 (1988) pp. 111-112.
Hylander et al., "Long-Term ECG Recording in Thyroxine-Substituted Hyopothyroid Subjects", Acta. Med. Scand., 222:429-432 (1987).
Paschen et al., "Alteration in Thyroid Hormone Concentration During and After Coronary Bypass Operation", Ann. Endocrinol., 44:239-242 (1983).
Xiang et al., "Effect of Myo-Inositol and T.sub.3 on Myocardial Lipids and Cardiac Function in Streptozocin.sup.3 Induced Diabetic Rats", Diabetes, 37:1542-1548 (1988).
Goodkind et al., "Effect of Thyroxine on Ventricular Myocardial Contractility and ATPase Activity in Guinea Pigs", Amer. J. Phys., 226:66-72 (1974).
Novitzky et al., "The Value of Triiodothyronine (T.sub.3) in the Rescue of a Failing Heart following Valve Replacement", The 23rd Annual Meeting of the Society of Thoracic Surgeons, Sep. 21-23, 1987 in Toronto, Ontario, Canada.
Hylander et al., "The Cardiovascular Response at Rest and During Exercise in Hypothyroid Subjects to Thyroxine Substitution", Clin. Cardiol., 6:116-124 (1983).
Labhart, "Clinical Endocrinology" Springer Verlag (1976) pp. 146-147.
Buccino et al., "Influence of the Thyroid State on the Intrinsic Contractile Properties and the Energy Stores of the Myocardium", J. Clin. Invest., 46:1669 (1967).
Wortsman et al., "Hypothyroxinemia in Cardiac Arrest", Arch. Intern. Med., 147:245-248 (1987).
Haynes et al., "Thyroid And Antithyroid Drugs" in: The Pharmacological Basis of Therapeutics, Gilman et al., eds., Macmillan Pub. Co. (1985).
Physicians Desk Reference Barnhart Publ., N.J. pp. 1558, 1801 and 962 (1990).
Bacci et al., "Cardiac Arrest After Intravenous Administration of Levothyroxine", J.A.M.A., 245:920 (1981).
Bergeron et al., "Myocardial Infarction, Severe Reversible Ischemia, and Shock Following Excess Thyroid Administration in a Woman With Normal Coronary Arteries", Arch. Intern. Med., 148:1450-1453 (1988).
Morkin et al., "Biochemical and Physiologic Effects of Thyroid Hormone on Cardiac Performance", Prog. Card. Dis., 25:435-464 (1983).
British Technology Group (U.S.A.)
Hollinden Gary E.
Raymond Richard L.
LandOfFree
Thyroid hormone treatment of acute cardiovascular compromise does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Thyroid hormone treatment of acute cardiovascular compromise, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Thyroid hormone treatment of acute cardiovascular compromise will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-905830