Pyrazinium substituted cephalosporins

Details Pyrazinium substituted cephalosporins Pyrazinium substituted cephalosporins

1981-10-02

1983-08-30

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544 22, A61K 31545, C07D50146

Patent

active

044016689

ABSTRACT:
Cephalosporin broad spectrum antibiotics represented by the formula ##STR1## wherein R' is an amino-substituted 5- or 6-membered nitrogen heterocyclic ring, eg. 2-aminothiazol-4-yl and 3-aminopyridin-1-yl; R" is hydrogen, C.sub.1 -C.sub.4 alkyl, a carboxy-substituted alkyl or cycloalkyl group, or a carbamoyl or substituted carbamoyl group; and R.sub.1 and R.sub.2 are hydrogen, C.sub.1 -C.sub.4 alkyl, mono or di(C.sub.1 -C.sub.4 alkyl)amino, mono or di(hydroxy-substituted C.sub.2 -C.sub.4 alkyl)amino; are provided. These betaine cephalosporins are provided in antibiotic formulations and are useful in a method for treating infections.

REFERENCES:
patent: 4024133 (1977-05-01), Cook et al.
patent: 4200575 (1980-04-01), Numata et al.
patent: 4258041 (1981-03-01), O'Callaghan et al.
patent: 4278671 (1981-07-01), Ochiai et al.
Derwent Abstract 32890.

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