Method of inducing bone growth using TGF-.beta.

Details Method of inducing bone growth using TGF-.beta. Method of inducing bone growth using TGF-.beta.

1989-09-01

1992-10-27

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 21, 514900, A61K 3724, A61K 3736

Patent

active

051589346

ABSTRACT:
A method is provided for generation of bone at a site of an animal where skeletal tissue is deficient comprising administering to the animal, locally at the bone site in the presence of a source of osteogenic cells, an effective amount of a composition comprising TGF-.beta. in a pharmaceutically acceptable carrier, provided that such composition excludes a bone morphogenetic cofactor, the composition being administered in an amount effective to induce bone growth at the bone site. Also provided is a device for implantation into a site of an animal where skeletal tissue is deficient comprising a device treated with an effective amount of a composition comprising TGF-.beta. and a source of osteogenic cells in a pharmaceutically acceptable carrier.

REFERENCES:
patent: 4563350 (1986-01-01), Nathan et al.
patent: 4642120 (1987-02-01), Neno et al.
patent: 4702734 (1987-10-01), Terranova et al.
patent: 4774228 (1988-09-01), Seyedin et al.
patent: 4774322 (1988-09-01), Seyedin et al.
patent: 4810691 (1989-03-01), Seyedin et al.
patent: 4843063 (1989-06-01), Seyedin et al.
patent: 4863732 (1989-09-01), Nathan et al.
patent: 4919939 (1990-04-01), Baker
patent: 4968590 (1990-11-01), Kuberasampath
Roberts & Sporn, Peptide Growth Factors and their Receptors I, Handbook of Exp. Pharmacology, vol. 95/1, Sporn & Roberts, eds., Springer-Verlag, (1990) Chapter 8.
Terranova et al., J. Period Res., 22: 248-251 (1987).
Sporn et al., J. Cell Biol., 105: 1039-1045 (1987).
Edwards et al., EMBO J., 6 (7): 1899-1904 (1987).
Bauer et al., PNAS USA 82: 4132-4136 (1985).
Brown et al., N. Eng. J. Med., 321 (2): 76-79 (1989).
Schultz et al., Science, 235: 350-352 (1987).
Mundy, J. N1H Res., 1: 65-68 (1989).
Bentz et al., J. Cell Biol., 107: 162a (1989) 918 abstract.
Pfeilschifter & Mundy, PNAS USA, 84: 2024-2028 (1987).
Ibbotson et al., J. Cell Biochem. Suppl., 10B, 108 (1986) H15 abst.
D'Souza et al., J. Bone & Min. Res., 1 (1): 74 (1986) 65 abst.
Roberts et al., J. Cell Biol., 103(5): 1a-624a: p. 10a (1986) 34 abst.
Wolf et al. Acta Endocrinal Suppl., 120: (1) p. 242 (1989) 260 abst.
Pfeilschifter et al., Acta Endocrinol. Suppl., 120: (1) 144-145 (1989).
Simpson Trends Biochem. Sci., 9: 527-530 (1984).
Valentin-Opran et al., Rev. Rhum. Mal. Osteoartic, 51 (11): 627-632 (1984) abstr. only.
Rosen, NY Acad. Sci. Mtg., Abstr. TGF-B, May 18-20, 1989 (abstr. 9).
Sodek et al., J. Dent. Res., 66: 191 (1987) 676 abstr.
Mundy, J. Dent. Res., 67: 108 (1988) 547 abstr.
Elford et al., Bone, 8: 259-262 (1987).
Burger et al., Calcif. Tiss. Int., 5-32 (F3).
Hayward & Fiedler-Nagy. Agents & Actions, 22: 251-254 (1987).
Russell, J. Dental Res., 66: 99 (538) (Mar. 1987).
Cotugno et al., J. Dental Res., 67: 185 (581) (Mar. 1988).
Sporn & Roberts, Nature, 332: 217-219 (1988).
Terranova & Wikesjo, J. Periodontal, 58(6): 371-380 (1987).
Terranova et al., J. Periodontol., 58(4): 247-257 (1987).
Terranova et al., J. Periodontal. Res., 21: 330-337 (1986).
Terranova & Lyall J. Periodontol., 57: 311-317 (1986).
Sampath et al., Proc. Natl. Acad. Sci USA, 84: 7109-7113 (1987).
Wang et al., Proc. Natl. Acad. Sci USA, 85: 9484-9488 (1988).
Wozney et al., Science, 242: 1528-1534 (1988).
Seyedin et al., J. Biol. Chem., 262: 1946-1949 (1987).
Seyedin et al. J. Biol. Chem, 261: 5693-5695 (1986).
Ibbotson et al., Science, 221: 1292-1294 (1983).
Hauschka et al., J. Biol. Chem, 261: 12665-12674 (1986).
Centrella et al., FASEB J, 2: 3066-3073 (1988).
Heine et al., J. Cell. Biol., 105: 2861-2876 (1987).
Sandberg et al., Development, 102: 461-470 (1988).
Sandberg et al., Devel. Biol., 130: 324-334 (1988).
Seyedin et al., Proc. Natl. Acad. Sci USA, 82: 2267-2271 (1985).
Carrington et al. J. Cell Biol., 107: 1969-1975 (1988).
Robey et al., J. Cell Biol., 105: 457-463 (1987).
Centrella et al., J. Biol. Chem., 262: 2869-2874 (1987).
Noda et al., J. Biol. Chem., 263: 13916-13921 (1988).
Wrana et al., J. Cell Biol., 106: 915-924 (1988).
Noda & Rodan, J. Cell. Physiol., 133: 426-437 (1987).
Pfeilschifter et al., Endocrinology, 121: 212-218 (1987).
Centrella et al., Endocrinology, 119: 2306-2312 (1986).
Noda, Endocrinology 124: 612-617 (1989).
Tashjian et al., Proc. Natl. Acad. Sci USA 82: 4535-4538 (1985).
Pfeilschifer et al., J. Clin Invest., 82: 680- 685 (1988).
Petkovich et al., J. Biol. Chem. 262: 13424-13428 (1987).
Chenu et al. Proc. Natl. Acad. Sci USA, 85: 5683-5687 (1988).
Creffo, et al., Calcified Tissue Internatl, 42: Suppl A15 (1988).
Ignotz & Massague, J. Biol. Chem., 261: 4337-4345 (1986).
Bolander et al., New York Academy of Sciences, "Transforming Growth Factor B5 Chemistry, Biology and Therapeutics", May 18-20, 1989.
Noda et al., J. Cell Biol., 107: 48a(1988) (6 Part 3).
Noda & Camilliere, Endocrinology, 124: 2991-2994 (1989).
Ibbotson et al., Proc. Natl. Acad. Sci USA, 83: 2228-2232 (1986).
Ammann et al., NY Acad. Sci Meeting (May 18, 1989).
Joyce et al., ASBMR/ICCRH Joint Meeting, 1989.
Sporn et al., Science, 219: 1329-1331 (1983).
Keshi-Oja et al., J. Cell Biochem., 33(2): 95-107 (1987).
Linkhart et al., Bone, 7: 479-487 (1986).
Rosen, NY Acad Sci Mtg, Abstr. on TGF.beta., May 18-20, 1989.
Wakley et al., Non-Cemented Total thp Arthroplasty, ed. Fitzgerald Jr. 99-109, Chapter 10 (Raven Press NY 1988).
Centrella et al., J. Cell Biol., 101: 245a (930) (1985).
Rosen et al., J. Cell Biol., 103: 446a (1661) (1986).
Chenu et al., Calcif. Tiss. Int., 42: A10(39) (1988).
Hock et al., Calcif. Tiss. In, 42: A32 (124) (1988).
Bentz et al., Devpmt & Diseases of Cartilage and Bone Matrix, UCLA Symp. Mol. Cell. Biol., 137-147 (1987).
Ibbotson et al., Devpmt & Diseases of Cartilage and Bone Matrix, UCLA Symp. Mol. Cell. Biol., 349-363 (1987).
Antosz & Aubin, J. Dent. Res., 67: 235 (983) (1988).
Kawamura & Urist, Dev. Biol., 130: 435-442 (1988).
Seyedin et al., J. Cell. Biochem. Supp., 10B: 105 (H9) (1986).
Komm et al., Science, 241: 81-84 (1988).
Terek et al., Clin. Res., 37(2): 462A (1989).
Globus et al., Endocrin., 123(1): 98-105 (1988).
Uneno et al., J. Bone & Min. Res., 4(2): 165-171 (1989).
Ibbotson et al., J. Bone & Min. Res., 4(1): 37-45 (1989).
Hiraki et al., Biochem & Biophys. Acta, 969: 91-99 (1988).
Pfeilschifter et al., Calcif. Tiss. Int., A34 (133).
Robey, Calcif. Tiss. Int., A34 (135).
Canalis et al., Calcif. Tiss. Int., 43: 346-351 (1988).
Guenther et al., J. Bone & Min. Res., 3(3): 269-278 (1988).
Roberts et al., Recent Progress in Hormone Res., 44: 157-197 (1988).
Rosen et al., J. Cell. Physiol., 134: 337-346 (1988).
Rodan et al., Calcif. Tiss. Int., 41:14 (Op10) (1987).
Stashenko et al., J. Dent. Res., 68(Spec. Issue): 192(84) (1989).
Hollinger et al., J. Dent. Res., 68 (Special Issue): 258(611) (1989).
Pfeilschifter & Mundy, Calcium Regulation & Bone Metabolism: Basic & Clinical Aspects, Cohn et al., eds., 450- 454 (1986).
Centrella et al., J. Cell Biol., 103: 444a (1656) (1986).
Stedman's Medical Dictionary, 24th ed., Williams and Wilkins, LA, 1984, p. 1058.
Noda & Rodan, Biochem. Biophys: Res. Comm., 140:56-65 (1988).
Jennings et al., J. Cell Physiol., 137:167-172 (1988).
Harrad et al., Calcif. Tiss. Int., 38: 316 (62) (1985).

Affiliated with

Also associated with

Rating

Method of inducing bone growth using TGF-.beta. does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of inducing bone growth using TGF-.beta., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of inducing bone growth using TGF-.beta. will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-905523