Method of using aminoarginine to block nitric oxide formation in

Details Method of using aminoarginine to block nitric oxide formation in Method of using aminoarginine to block nitric oxide formation in

1991-03-19

1992-10-27

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435114, 514565, C12N 506

Patent

active

051588838

ABSTRACT:
Pharmaceutically pure physiologically active N.sup.G -aminoarginine (i.e., the L or D,L form) or pharmaceutically acceptable salt thereof is administered in a nitric oxide synthesis inhibiting amount to a subject in need of such inhibition (e.g. a subject with low blood pressure or needing immunosuppressive effect) or is added to a medium containing isolated organs, intact cells, cell homogenates or tissue homogenates in an amount sufficient to inhibit nitric oxide formation to elucide or control the biosynthesis, metabolism or physiological role of nitric oxide.
N.sup.G -amino-L-arginine is prepared and isolated as a pharmaceutically pure compound by reducing N.sup.G -nitro-L-arginine, converting L-arginine by-product to L-ornithine with arginase and separating N.sup.G -amino-L-arginine from the L-ornithine. N.sup.G -amino-D,L-arginine is prepared in similar fashion starting with N.sup.G -nitro-D,L-arginine.

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