2-Amino-4,5-dihydropyridine derivatives

Details 2-Amino-4,5-dihydropyridine derivatives 2-Amino-4,5-dihydropyridine derivatives

1973-07-30

1976-05-25

Winters, Sherman D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260243B, 260251R, 2602948D, 2602564R, 260268R, 2602948F, 260268H, 260268FT, 2602948G, 260287R, 260289R, 2602949, 26029387, 424246, 260295AM, 424248, 424250, 260295R, 424251, 424258, 2602955R, 424266, 2602955A, 260297R, 2603262, 26032647, 2603265R, 2603265J, 2603322A, 2603323R, 2603473, 2603474, 2603478, 260470, 260471R, 260473R, 260476R, 260482R, 260483, 260590R, 260593R, 260239BF, 260240R, 2602471M, 2602472A, 2602472B, C07D29514

Patent

active

039592928

ABSTRACT:
4,5-Dihydropyridines bearing an N,N-disubstituted amino group in the 2-position, carbonyl functions in the 3- and 5-positions and being optionally substituted in the 6-position by lower alkyl or phenyl and, in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-pyrrolidino-6-methyl-4-(3-nitrophenyl)-4,5-dihydropyridine-3,5-dicarboxy lic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a substituted 3,3-diaminoacrylate.

REFERENCES:
patent: 3441648 (1969-04-01), Loev et al.
patent: 3485847 (1969-12-01), Bossert et al.
patent: 3488359 (1970-01-01), Bossert et al.
patent: 3708489 (1973-01-01), Rucker et al.
patent: 3773773 (1973-11-01), Bossert

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