Amino-derivatives of 1,4-benzodioxan

Details Amino-derivatives of 1,4-benzodioxan Amino-derivatives of 1,4-benzodioxan

1975-01-17

1976-05-25

Rollins, Alton D.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424250, C07D29510, A61K 31495, C07D40506

Patent

active

039592839

ABSTRACT:
1-[2-(1,4-Benzodioxanyl)methyl]-4-(2-hydroxyethyl)-piperazine hemifumarate and the related compounds of formula: ##SPC1##
In which R is hydrogen or alkyl; and A is --CH(CH.sub.3)COOC.sub.2 H.sub.5, --CH.sub.2 CH.sub.2 O(C.sub.6 H.sub.4) (CH.sub.3).sub.2, --CH.sub.2 CH(OH)Ph or --CH.sub.2 CO(C.sub.6 H.sub.3) (OCH.sub.3).sub.3 or A is --Z--OR.sub.1, --CH.sub. 2 CHOR".sub.1 CH.sub. 2 OR'.sub.1, --Z--CO--B or amidino, where Z is a linear or branched divalent hydrocarbon chain of 1 to 3 carbon atoms, R'.sub.1 and R".sub.1, which may be indentical or different, are each hydrogen, alkyl, or acyl, B is OH, alkoxy, or a secondary, tertiary or N-heterocyclic amino radical, and R.sub.1 is alkyl, acyl other than nicotinoyl or 3,4,5-trimethoxy-benzoyl, or, when R is other than hydrogen, hydrogen, and its acid addition salts, are useful in therapy as vasodilators and .alpha.-blocking agents.

REFERENCES:
mndzhoyan, A. L. et al., C.A. Vol. 70, p. 96754t, (1969).

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