Method of preparing controlled long-acting pharmaceutical formul

Details Method of preparing controlled long-acting pharmaceutical formul Method of preparing controlled long-acting pharmaceutical formul

1988-07-12

1989-08-08

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424470, 424488, 424494, A61K 922, A61K 926

Patent

active

048551430

ABSTRACT:
A method of preparing a multiplicity of controlled, long-acting release pharmaceutical tablets, each containing a therapeutic agent and a cellulosic ether carrier base material is shown. The method includes the steps of adding a quantity of cellulose ether base material such as hydroxypropyl methylcellulose and an active therapeutic agent to form a mixture, thoroughly and uniformly mixing that mixture, discontinuing the mixing, permitting the uniform mixture to stand for a period of time, typically two to twenty-four hours or longer, sufficient to cause the therapeutic agent to become bonded to the carrier base material and compressing portions of the mixture to form the solid unit dose tablets. The advantage of the method is that the time release of each tablet from a given batch of formulation and the time release characteristics of tablets prepared in different batches, will be substantially more uniform and comparable.

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