Buccal tablet comprising etorphine or a salt thereof

Details Buccal tablet comprising etorphine or a salt thereof Buccal tablet comprising etorphine or a salt thereof

1987-04-10

1989-05-09

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514809, 514974, 514816, 514817, 514818, 514948, 424464, 424465, A61K 922, A61K 952, A61K 920, A61K 926

Patent

active

048290564

ABSTRACT:
Pharmaceutical compositions in the form of a buccal tablet comprising etorphine or a salt thereof, at least one monosaccharide, disaccharide or a mixture thereof, and a mixture of xanthan gum and locust bean gum in a weight ratio 3:1 to 1:1, wherein the total weight of the mono- and/or di-saccharides relative to the combined weight of the xanthan and locust bean gums is in the ratio of 20:1 to 3:1. The tablet affords improved bioavailability.

REFERENCES:
patent: 2407486 (1946-09-01), Flenner et al.
patent: 3218232 (1965-11-01), Stein et al.
patent: 4076804 (1978-02-01), Singiser
patent: 4126684 (1978-11-01), Robson et al.
patent: 4244944 (1981-01-01), Wilkinson
patent: 4244945 (1981-01-01), Wilkinson
patent: 4315936 (1982-02-01), Capetola et al.
patent: 4559326 (1985-12-01), Crawford et al.
patent: 4598087 (1966-07-01), Horwell
patent: 4599342 (1986-07-01), LaHann
patent: 4673679 (1987-06-01), Aungst et al.
Pharmacodynamics, vol. 68, 1986, p. 1890.

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