Method for treating asthma using optically pure R(-) salmeterol

Details Method for treating asthma using optically pure R(-) salmeterol Method for treating asthma using optically pure R(-) salmeterol

1997-12-17

1999-07-06

Jarvis, William R. A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514649, A61K 31135

Patent

active

059198273

ABSTRACT:
The optically pure R(-) isomer of salmeterol, which is substantially free of the S(+) isomer, is a potent bronchodilator for relieving the symptoms associated with asthma in individuals. A method is disclosed utilizing the optically pure R(-) isomer of salmeterol for treating asthma while minimizing toxicity and other side effects associated with salmeterol.

REFERENCES:
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Larsson, Chem. Abst. 114(3): 1694lr; "Long-term Studies on Long Acting Sympathomimetics", Lung 168 (Suppl), 22-24 (1990).
Johnson, Chem. Abst. 114(3): 16944u: "The Pharmacology of Salmeterol", Lung 168 (Suppl.) 115-119 (1990).
Chem. Abst. 114 (7): 55571q; Brittain, "Approaches to a Long-Acting, Selective beta.sub.2 -adrenoceptor Stimulant", Lung 168 (Suppl.), 111-114 (1990).
World Patent Index Acc. No.: 84-264874/43; DE 3414752, Oct. 18, 1984, Skidmore et al., New Phenyl Amino Ethanol Derivative.
Jamali et al., "Enantioselective Aspects of Drug Action and Disposition: Therapeutic Pitfalls", J. Pharma. Sci. 78(9), 695-711 (1989).

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