Method of alleviating pain

Details Method of alleviating pain Method of alleviating pain

1997-08-01

1999-07-06

Fay, Zohreh

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514646, A61K 31165

Patent

active

059198265

ABSTRACT:
The analgesic effectiveness of an tramadol is significantly enhanced by administering tramadol with the administration of an analgesia-enhancer which is a nontoxic NMDA receptor blocker and/or a nontoxic substance that blocks at least one major intracellular consequence of NMDA receptor activation.

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Price et al., "Effects of the combined oral administration of NSAIDS, and dextromethorphanon on behavioral symptons indicative of arthritic pain in rats", Pain vol. 68, No. 1, pp. 119-127 (1996).
Lehmann, "Tramadol for the Management of Acute Pain", Drugs vol. 47, No. S1, pp. 19-32 (1994).
Sefrin, "Therapie des akuten Schmerzes im Rahmen der Notfallmedizin", Notfallmedizin vol. 23, No. 4, pp. 148-156 (1997).
Lipman, "Analgesic Drugs for Neuropathic and Sympathetically Maintained Pain", Clinics in Geriatric Medicine-Pain Management, vol. 12, No. 3 Aug. 1996, pp. 501-515.
Bession, "La Complexite des aspects Physiopharmacologiques de la Douleur", Drugs vol. 53, No. 52, pp. 1-9 (1997).

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