Pyrroles as sPLA.sub.2 inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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514423, 514424, 514427, 548413, 548530, 548539, 548540, 548550, 548561, A61K 3140, C07D207323, C07D20736, C07F 9572

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active

059197749

ABSTRACT:
A class of novel pyrroles is disclosed together with the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.

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Kim, et al., Tetrahedron Letters, 1994, 35(19), 3017.
Pataki, et al., J. Org. Chem., 1982, 47,1133.
Reetz, et al., J. Org. Chem., 1983, 48, 254.

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