Method for treating acute and severe diarrhea

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514281, 514282, 514424, 514812, 514867, A61K 3812, A01N 4342, A01N 4346

Patent

active

059197609

ABSTRACT:
The invention provides a method for treating acute and severe diarrhea such as that which accompanies chemotherapy and rapid narcotic detoxification. The method includes administering octreotide in an amount sufficient to alleviate the diarrhea without precipitating clinically significant bradycardia. In a preferred embodiment an anticholenergic is administered together with octreotide to further reduce the possibility of significant bradycardia. The invention also provides a method for rapidly detoxifying a patient addicted to narcotics. Acute and severe diarrhea is eliminated during detoxification by administering octreotide in according to the above-described method.

REFERENCES:
patent: 3896226 (1975-07-01), Fishman
patent: 4535157 (1985-08-01), Meltzer et al.
patent: 4987136 (1991-01-01), Krook et al.
patent: 5272149 (1993-12-01), Stalling
patent: 5789411 (1998-08-01), Gooberman et al.
Gerra et al., "Clonidine and Opiate Receptor Antagonists in the Treatment of Heroin Addiction". Journal of Substance Abuse Treatment, vol. 12, No. 1. pp. 35-41. 1995.
Loimer et al., "Continuous Naloxone Administration Suppresses Opiate Withdrawal Symptoms In Huamn Opiate Addicts During Detoxification Treatment". 1989 pp. 81-86.
Text--Opioid Peptides in Substance Abuse by Jozsef I. Szekely. CRC Press, Inc., p. 160 (1994).
Article--Spanagel et al.--"Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway" Proc. Natl. Acad. Sci. USA vol. 89. p. 2046. Mar. 1992.
Article--Pan et al. "Cellular mechanism for anti-analgesic action of agonists of the k-opioid receptor" Nature vol. 389/25 Sep., pp. 382-385.
Article--Kreeks et al. "Orally Administered opioid antagonists reverse both mu and kappa opioid agonists delay of gastrointestinal transit in the guinea pig" Life Sciences, vol. 56. No. 14. pp. 1187-1192. 1995.
Article--Arts et al. "Inhibition of the Antianalgesic Action of Dynorphin A in Mice by Cholera Toxin" Pharacology Biochemistry and Behavior, vol. 46. pp. 623-629. 1993.
Article--Bakashi et al. "Dynorphin A-(1-17) Induces Alterations in Free Fatty Acids, Excitatory Amino Acids, and Motor Function Through An Opiate-Receptor-Mediated Mechanism" The Journal of Neuroscience, Dec. 1990. 10(12):3793-3800.
Article--Behrmann et al. "A Comparison of YM-14673. U-50488H, and Nalmefene after Spinal Cord Injury in the Rat" Experimental Neurology 119. 258-267 (1993).
Article--Ohnishi et al. "Aquaretic Effect of the Stable Dynorphin-A analog E2078 in the Human" The Journal of Pharmacology and Experimental Therapeutics vol. 270. No. 1. Mar. 19, 1994. -D-LCU.sup.8 !--Dynorphin-A-(1-8)Ethylamide, a Stable Dynorphin Analog. Produces Diuresis by Kappa-Opiate Receptor Activation in the Rat" The Journal of Pharmacology and Experimental Therapeutics vol. 262. No. 3. 1992.
Article--Wang et al. "Contribution of Alpha-2 adrenoceptors to Kappa Opioid Agonist-Induced Water Diuresis in the Rat" The Journal of Pharmacology and Experimental Therapautics vol. 270. 1994.
Article--O'Connor et al. Rapid and Ultrarapid Opioid Detoxification Techniques JAMA. Jan. 21. 1998--vol. 279, No. 3.
Partridge et al., "Pulmonary Edema Following Low-dose Naloxone Administration". Anesthesiology. vol. 65. No. 6. pp. 709-710. 1986.
Taff. "Pulmonary Edema Following Naloxone Administration in a Patient Without Heart Disease". Anesthesiology. 59. 576-77. 1983.
San et al. "High Risk of Ultrashort Noinvasive Opiate Detoxification". Am. J. Psychiatry 152. p. 956. Jun. 1995.
Brewer. C., Ultra-rapid, antagonist-precipitated opiate detoxification under general anesthesia or sedation. Addiction Biology 2/3. pp. 291-302. 1997.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for treating acute and severe diarrhea does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for treating acute and severe diarrhea, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for treating acute and severe diarrhea will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-899037

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.