Polynucleotides encoding cytokine inducible regulatory protein

Details Polynucleotides encoding cytokine inducible regulatory protein Polynucleotides encoding cytokine inducible regulatory protein

1997-08-25

1999-07-06

Mertz, Prema

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

435 712, 4352523, 4353201, 435325, 435471, 536 235, 536 2431, 530350, 514 44, C12N 1512, C12N 1563, C07K 1447

Patent

active

059196610

ABSTRACT:
The invention provides a human cytokine inducible regulatory protein (CIRP-1) and polynucleotides which identify and encode CIRP-1. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of CIRP-1.

REFERENCES:
Callard, R., et al., "The Cytokine Facts Book", 2-6 (1994).
Lowenstein, E.J., "The SH2 and SH3 Domain-Containing Protein GRB2 Links Receptor Tyrosine Kinases to ras Signaling", Cell, 70:431-442 (1992).
Yoshimura, A., et al., "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors", The EMBO Journal, 14(12): 2816-2826 (1995). (GI 1041129) (GI 1041128) (1995).
Yoshimura, A., et al., (GI 1041129) GenBank Sequence Database (Accession D31943), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 1041128) (1995).
Yoshimura, A., et al., (GI 1041128) GenBank Sequence Database (Accession D31943), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. (GI 1041129).
George et al. (1988) Ch. 12. Macromolecular Sequencing & Synthesis Selected Methods & Applications, pp. 127-149, Alan R. Liss, Inc.
Cunningham et al. (1989) Science vol. 244, pp. 1081-1085.

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