Method of determining the degree of aggregation of the .beta.-A4

Details Method of determining the degree of aggregation of the .beta.-A4 Method of determining the degree of aggregation of the .beta.-A4

1996-07-17

1999-07-06

Duffy, Patricia A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

436164, 436171, G01N 3353

Patent

active

059196319

ABSTRACT:
A method of determining the degree of aggregation of the .beta.A4 peptide is disclosed. The method comprises reacting the protein with a suitable binding agent which is capable of binding the .beta.A4 peptide only in its non-aggregated state to form an amount of protein bound binding reagent. The amount of protein bound binding agent is then measured.

REFERENCES:
Sedmak, et al., Analytical Biochemistry 79, pp. 544-552, (1977).
Jarrett, et al., Cell, vol. 73, pp. 1055-1058 (1993).
Compton, et al., Analytical Biochemistry 151, pp. 369-374 (1985).
D.J. Selkoe, Scientific American, pp. 68-78 (1991).
M.M. Bradford, Analytical Biochemistry 72, pp. 248-254 (1976).
H. LeVine, Protein Science 2, pp. 404-410 (1993).
G. Perry et al., Brain Researach, vol. 420, pp. 233-242 (1987).

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