Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1997-10-29
1999-07-06
Hendricks, Keith D.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435193, 4352523, 4353201, 435325, 435419, 536 232, C12N 910, C12N 1554
Patent
active
059196270
ABSTRACT:
The invention provides a human microsomal glutathione-S-transferase (MGST) and polynucleotides which identify and encode MGST. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of MGST.
REFERENCES:
Thier, R. et al., "Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes",Proc. Natl. Acad. Sci. USA , 90:8567-8580 (1993).
Simula, T.P. et al., "Human glutathione S-transferase-expressing Salmonella typhimurium tester strains to study the activation/detoxification of mutagenic compounds: studies with halogenated compounds, aromatic amines and aflatoxin B.sub.1 ", Carcinogenesis 14(7):1371-1376 (1993).
Dirven, H.A.A.M. et al., "Involvement of Human Glutathione S-Transferase Isoenzymes in the Conjugation of Cyclophosphamide Metabolites with Glutathione", Cancer Res. 54:6215-6220 (1994).
Jakobsson, P.J. et al., (GI 1747520) GenBank Sequence Database (Accession U77604), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 (GI 1747521) 1996.
Jakobsson, P. et al., "Identification and Charactization of a Novel Human Microsomal Glutathione S-Transferase with Leukotriene C.sub.4 Synthase Activity and Significant Sequence Identity to 5-Lipoxygenase-activating Protein and Leukotriene C.sub.4 Synthase", The Journal of Biological Chemistry, 271:22203-22210 (1996). (GI 1747521).
Hillier, L. et al., (GI 1390323) GenBank Sequence Database (Accession W79905), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849. Oct. 15, 1996.
Hillier, L. et al., (GI 1365407) GenBank Sequence Database (Accession W58675), National Center for Biotechnology Information: National Library of Medicine, Bethesda, Maryland 20849 Oct. 17, 1996.
Kelner et al. Genomics, vol. 36, 1996, pp. 100-103.
Jakobsson et al., J. Biol. Chem., 272(36):22934-22939, 1997.
Corley Neil C.
Lal Preeti
Shah Purvi
Hendricks Keith D.
Incyte Pharmaceuticals Inc.
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