Therapeutically useful tetralin derivatives

Details Therapeutically useful tetralin derivatives Therapeutically useful tetralin derivatives

1992-04-10

1993-05-25

Robinson, Allen J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

514438, 514654, 514657, 564374, 564382, 564428, C07P33320, A61K 3138, A61K 31135, C07C21100

Patent

active

052141560

ABSTRACT:
This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of the formula ##STR1## wherein YR.sub.1 is OR.sub.1 at the 8 position where R.sub.1 is --CH.sub.2 --(C.sub.3-8 cycloalkyl);

REFERENCES:
patent: 3253037 (1966-05-01), Huebner
patent: 4564628 (1986-01-01), Horn
Wikstrom, H. et al., "Conformational Analysis of 2-Aminoindans and 2-(Aminomethyl)indans in Relation to Their Central Dopaminergic Effects and a Dynamic Dopamine Receptor Concept," J. Med. Chem. 30(7):1115-20 (1987).
Cannon, J. G. et al., "Conformationally Restricted Congeners of Dopamine Derived from 2-Aminoindan," J. Med. Chem. 25:1442-46 (1982).
Dren, A. T. et al., "Local Anesthetic Activity and Acute Toxicity of N-Substituted 1,2,3,4-Tetrahydro-1-and 2-naphthylamines," J. Pharmaceutical Sciences 67(6):880-82 (1978).
Ames, D. E. et al., "The Synthesis of Alkoxy-1,2,3,4-tetrahydronaphthalene Derivatives. Part I.2-Amino--, Alkylamino-, and Dialkylamino-derivatives," J. Chem. Soc. 2636-41 (1965).
Arvidsson, L.-E. et al., "8-Hydroxy-2-(alkylamino)tetralins and Related Compounds as Central 5-Hydroxytryptamine Receptor Agonists," J. Med. Chem. 27:45-51 (1984).
"Arvidsson, L.-E. et al., 8-Hydroxy-2-(di-n-propylamino)tetralin, a New Centrally Acting 5-Hydroxytryptamine Receptor Agonist," J. Med. Chem. 24:921-23 (1981).
McDermed, J. D. et al., "Synthesis and Dopaminergic Activity of (.+-.)-, (+)-, and (-)-2-Dipropylamino-5-hydroxy-1,2,3,4-tetrahydronaphthalene," J. Med. Chem. 19(4):547-49 (1976).
McDermed, J. D. et al., "Synthesis and Pharmacology of Some 2-Aminotetralins. Dopamine Receptor Agonists," J. Med. Chem. 18(4):362-67 (1975).
Arvidsson, L.-E. et al., "(+)-c-8-Hydroxy-1-methyl-2-(di-n-proplyamino)tetralin: A Potent and Highly Stereoselective 5-Hydroxytryptamine Receptor Agonist," J. Med. Chem. 30:2105-09 (1987).
Rusterholz, D. B. and C. F. Barfknecht, "Ergoline Congeners as Potential Inhibitors of Prolactin Release," J. Med. Chem. 19(1):99-102 (1976).
Cannon, J. G. et al., "Synthesis and Dopaminergic Activity of (R)-and (S)-4-Hydroxy-2-(di-n-propylamino)indan," J. Med. Chem. 28:515-18 (1985).
Temple, D. M., "Some New Sympathomimetic Amines: N-Cycloalkyl Derivatives of 1,2,3,4-Tetrahydro-2-Naphthylamine and of Noradrenalone," Aust. J. Chem. 20:601-04 (1967).

Affiliated with

Also associated with

Rating

Therapeutically useful tetralin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Therapeutically useful tetralin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Therapeutically useful tetralin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-898249