Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1978-02-17
1980-07-29
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
424180, 536 18, 536120, C07H 1512, C07H 1702
Patent
active
RE0303542
ABSTRACT:
The invention provides a novel therapeutic composition comprising a pharmaceutically acceptable carrier containing a therapeutically effective amount of an ethereally monosubstituted monosaccharide having the general formula S--O--Y, wherein S is the residue of a monosaccharide selected from the group consisting of pentoses, hexoses and heptoses and Y is selected from the group consisting of cyclic monovalent nitrogen containing organic radicals and residua and monovalent organic radicals and residua having the general formula ##STR1## wherein R.sub.1 is a divalent organic radical having a linear carbon chain length of about 1-7 carbon atoms and R.sub.2 and R.sub.3 are selected from the group consisting of --H, --OH, --SH, halogen and monovalent organic radicals and residua having a linear carbon chain length of about 1-7 carbon atoms. The invention also provides certain novel ethereally monosubstituted monosaccharides, of which 3-O-3'-(N',N'-dimethylamino-n-propyl)-D-glucose is an example. The novel monosaccharides show striking antiviral activity or other therapeutically valuable properties and are useful as an active ingredient in the above therapeutic composition. The invention further provides a method of therapeutically treating warm blooded animals with the aforementioned therapeutic composition and novel monosubstituted monosaccharides.
REFERENCES:
patent: 2374236 (1945-04-01), Salzberg et al.
patent: 2785152 (1957-03-01), Jonas
patent: 3723617 (1973-03-01), Sutton
Roberts et al., "Canadian Jour. of Chem.," vol. 45, 1967, pp. 261-265.
Corbett, "Jour. Chem. Soc.," 1961, pp. 2926-2930.
Roberts et al., "Canadian Jour. of Chem.," vol. 47, 1969, pp. 1571-1580.
Brown Johnnie R.
Strategic Medical Research Corp.
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