N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives, and the pha

Details N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives, and the pha N.sup.2 -Naphthalenesulfonyl-L-arginine derivatives, and the pha

1977-10-21

1979-09-18

Raymond, Richard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

2601125R, 260239A, 260239E, 260239BF, 26032633, 26050112, 26050114, 260556B, 424177, 424267, 424274, 424316, 424321, 546205, A61K 31445, C07D21116

Patent

active

041683072

ABSTRACT:
N.sup.2 -naphthalenesulfonyl-L-arginine amides having the formula ##STR1## or the acid addition salts thereof with a pharmaceutically acceptable acid wherein R.sub.1 is alkenyl of not more than 10 carbon atoms, or substituted alkyl containing not more than 20 carbon atoms wherein said substituent is a member selected from the class consisting of alkoxy, alkoxycarbonyl, arylcarbamoyl acyl, acyloxy, N,N-polymethylenecarbamoyl and carboxy, and R.sub.2 is aryl, cycloalkyl, aralkyl or cycloalkylalkyl, respectively containing not more than 15 carbon atoms and R' is 1-naphthyl substituted with a member selected from the class consisting of 2-dialkylamino, 3-dialkylamino, 4-dialkylamino, 6-dialkylamino, 7-dialkylamino, 8-dialkylamino, respectively containing not more than 20 carbon atoms, and 5-dialkylamino containing 3-20 carbon atoms; or 2-naphthyl substituted with dialkylamino containing not more than 20 carbon atoms.

REFERENCES:
patent: 3978045 (1976-08-01), Okamoto et al.

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