Method for producing an animal model for inflammatory bowel dise

Details Method for producing an animal model for inflammatory bowel dise Method for producing an animal model for inflammatory bowel dise

1990-04-18

1993-05-25

Low, Christopher S. F.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514557, 514628, 800 2, 4351721, 424 9, A01N 4336, A61K 3140

Patent

active

052140660

ABSTRACT:
A new animal model for Inflammatory Bowel Disease, including idiopathic ulcerative colitis and Chron's disease, as well as methods for problems such as an animal, is provided. Chronic ulcerative condition is induced by topical administration of a sulfhydryl blocker, such as N-ethylmaleimide or iodoacetamide, to the colon. The new animal model is useful for studying the pathogenesis of chronic ulcerative disease, and prevention and treatment thereof, and for evaluating drugs suspected of being useful in the treatment of same.

REFERENCES:
Kilbey et al. (eds.) 1984 in: Handbook of Mutogenicity Test Procedures Second Edition. Elsevier, N.Y. pp. 485-494.
Szabo, S., Am. J. Path. 93:273-276 (1978).
Szabo, S. et al., Science 214:200-202 (1981).
Szabo, S. et al., Drugs and Peptic Ulcer, CRC Press, pp. 55-74 (1982).
Szabo, S. et al., Gastroent. 86:1271 (1984).
Szabo, S., Gastroent. 87:228-229 (1984).
Szabo, S., Digestive Diseases and Sciences 30:28S-31S (1985).
Szabo, S. et al., J. Pharm. Methods 13:59-66 (1985).
Szabo, S. et al., Gastroent. 88:228-236 (1985).
Szabo, S. et al., Scand. J. Gastroent. 21 (Suppl. 125): 92-96 (1986).
Szabo, S. et al., Toxicol. Path. 16:205-212 (1988).
Szabo, S. et al., Digestive Diseases and Sciences 34: 1323 (1989).
Dupuy, D. et al., Ulcer Diseases: New Aspects of Pathology and Pharmacology, CRC Press, pp. 421-434 (1989).
Satoh, H. et al., Gastroent. 98:A202 (1990).
Beeken, W. L., "Experimental Inflammatory Bowel Disease" in: Kirsner, J. B., et al., eds., Inflammatory Bowel Disease, Lea and Febiger, Philadelphia, pp. 37-49 (1988).
Benitz, K. F. et al., Fd. Cosmet. Toxicol. 11:565-575 (1973).
Berger, R. L. et al., Annals of Surgery 152:266-273 (1960).
Engster, M. et al., Toxicol. and Applied Pharm. 38:265-282 (1976).
Ger, R. et al., Dis. Col. & Rect. 29:177-181 (1986).
Krasna, I. H. et al., J. Ped. Surgery 21:26-29 (1986).
Morris, G. P. et al., Gastroent. 96:795-803 (1989).
Onderdonk, A. B. et al., Am. J. Clin. Nut. 32:258-265 (1979).
Onderdonk, A. B., Digestive Diseases and Sciences 30 (Dec. Suppl.):40S-44S (1985).
Strober, W., Digestive Diseases and Sciences 30 (Dec. Suppl.):3S-10S (1985).
von Ritter, C. et al., Gastroent. 95:651-656 (1988).
von Ritter, C. et al., Gastroent. 96:811-816 (1989).

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