Proline derivatives

Details Proline derivatives Proline derivatives

1997-08-22

1998-09-15

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D207323

Patent

active

058080970

ABSTRACT:
The present invention relates to particular forms of a novel ide which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes pharmaceutical compositions containing such forms, processes for preparing the forms and intermediates useful in the synthesis of the forms.

REFERENCES:
patent: 4277395 (1981-07-01), Bey et al.
patent: 4518528 (1985-05-01), Rasnick
patent: 4596789 (1986-06-01), Dutta et al.
patent: 4910190 (1990-03-01), Bergeson et al.
patent: 5055450 (1991-10-01), Edwards et al.
patent: 5194588 (1993-03-01), Edwards et al.
patent: 5414132 (1995-05-01), Stein et al.
Imperiali, B. & Abeles, R. H. Biochemistry (1986), 25, 3760-3767 (including twenty (20) pages of supp. material).
Imperiali, B. & Abeles, R. H. Tetrahedron Lett. (1986), 27, 135-138.
Chem. Abstr. vol. 92, (1980), 175119.
Chem. Abstr. vol. 102, (1985), 84468.
Gelb, M. H., Svaren, J.P., & Abeles, R. H. Biochemistry (1985), 24, 1813-1817.
Prestwich, G. D., et al. Archives of Biochemistry and Biophysics (1984), 228, 639-645.
Abdel-Aal, et al. Pesticide Biochemistry and Physiology (1984), 21, 232-241.
Hammock, B. D., et al. Pesticide Biochemistry and Physiology (1982), 17, 76-88.
Brodbeck, U., et al. Biochimica et Biophysica Acta (1979), 567, 357-369.
Kingsbury, C. A., et al. J. Chem. Soc. Perkin Trans. II (1982), 867.
McBee, E.T., et al. J. Amer. Chem. Soc. (1956), 78, 4053.
Cook, D. J., et al. J. Amer. Chem. Soc. (1954), 76, 83.
Powers et al. Biochimica et Biophysica Acta (1977), 485: 156-166.
Chemical Abstracts, vol. 99, No. 21, 21st Nov. 1983, p. 547, Abstract No. 174904g, Columbus, Ohio, US; D.B. Dess et al.; "Readily accessible 12-I-5 oxidant for the conversion of primary and secondary alcohols to aldehydes and ketones" J. Org. Chem. 1983, 48(22), 4155-6.
Rich, D. H., et al., Biochem. Biophys. Res. Comm. 1982 104(2), 1127-1133.
Hori, H., et al., Proc. 9th American Peptide Symposium, Toronto, Jun. 1985, pp. 819-922.
Thaisrivongs, S., J. Med. Chem., 1985, 28, 1553-1555.
Edwards, P.D. (1992) (Tetrahedron Letters 33(30):4279-4282.

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