Process for preparing active carbonates of polyalkylene oxides f

Details Process for preparing active carbonates of polyalkylene oxides f Process for preparing active carbonates of polyalkylene oxides f

1997-01-21

1998-09-15

Stucker, Jeffrey

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548542, C07D20740, C07D20746

Patent

active

058080961

ABSTRACT:
Poly(ethylene glycol)-N-succinimide carbonate and its preparation are disclosed. Polyethylene glycol (PEG) is converted into its N-succinimide carbonate derivative. This form of the polymer reacts readily with amino groups of proteins in aqueous buffers. The modified proteins have PEG-chains grafted onto the polypeptide backbone by means of stable, hydrolysis-resistant urethane (carbamate) linkages.

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