Substituted acyloxyalkylphenylethylene inhibitors of 3-hydroxy-3

Details Substituted acyloxyalkylphenylethylene inhibitors of 3-hydroxy-3 Substituted acyloxyalkylphenylethylene inhibitors of 3-hydroxy-3

1987-09-11

1989-03-14

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30930

Patent

active

048125830

ABSTRACT:
Compounds of the formula: ##STR1## where M is hydrogen or alkyl; R.sup.2 and R.sup.3 are, independently, alkyl; R.sup.4 is hydrogen, alkyl, phenyl or substituted phenyl, trifluoromethyl; and R.sup.5 is alkyl, phenyl or substituted phenyl, alkoxy, or trifluoromethyl; or a pharmaceutically acceptable salt thereof, are hypocholesteremic agents.

REFERENCES:
patent: 4375475 (1983-03-01), Willard et al.
patent: 4571428 (1986-02-01), Kapa
patent: 4613610 (1986-09-01), Wareing
patent: 4654363 (1987-03-01), Prugh
patent: 4661483 (1987-04-01), Hoffman et al.
Derwent 84-201398/32 (Abstract of WO 8402-903).
Hoffman et al., J. Med. Chem. 29, 159 (1986).
Rosen et al., J. Am. Chem. Soc. 107, 3731 (1985).
Sato et al., Chem. Pharm. Bull. 28(5), 1509-1525 (1980).
Sletzinger et al., Tetrahedron Letters 26, 2951 (1985).
Stokker et al., J. Med. Chem. 28, 347 (1985).
Stokker et al., J. Med. Chem. 29, 170 (1986).

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