Process for the preparation of 4-phenylpyrrole derivatives

Details Process for the preparation of 4-phenylpyrrole derivatives Process for the preparation of 4-phenylpyrrole derivatives

1987-09-04

1989-03-14

Brust, Joseph Paul

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548530, 548531, C07D207335

Patent

active

048125806

ABSTRACT:
The invention relates to a process for the preparation of 4-phenylpyrrole derivatives of the formula I ##STR1## wherein R.sub.n, R.sub.1 and R.sub.2 are as defined in claim 1, which comprises reacting a phenacylamine of formula II ##STR2## with a compound of formula III

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Tetrahedron Letters No. 52, pp. 5337-5340 (1972), Van Leusen et al.
John M. Patterson; Recent Synthetic Methods for Pyrroles & Pyrrolenines, pp. 281-304 (1976).
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Chemical Abstracts, vol. 78, Jan.-Jun. 1973; Van Leusen et al: 111044x.
John D. Roberts, et al., Basic Principles of Organic Chemistry, pp. 320-321 (date unknown).
Noller, "Chemistry of Organic Compounds", 3rd ed, (1965), pp. 258-259; W. B. Saunders Co., Philadelphia and London.

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