Preparation of fluoropyridines

Details Preparation of fluoropyridines Preparation of fluoropyridines

1987-10-21

1988-11-01

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546287, 546346, C07D21357, C07D21326, C07D21302

Patent

active

047821612

ABSTRACT:
Fluoropyridine compounds, including 3- and 5-fluoropyridines, are prepared in an improved process by contacting chloropyridine compounds with hydrogen fluoride in the vapor phase in the presence of an activated carbon catalyst having large diameter pores. Thus, 2,3-difluoro-5-(trifluoromethyl)pyridine is prepared by contacting 3-chloro-2-fluoro-5-(trifluoro-methyl)pyridine with excess hydrogen fluoride at about 500.degree. C. in the presence of an activated carbon catalyst having an average pore diameter of about 100 Angstroms.

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