Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-10-17
1998-09-15
Kight, John
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
56 271, 56 285, 56 2851, 56 2852, 56124, C07H 1909
Patent
active
058080473
ABSTRACT:
A process for the preparation of compounds of the formula: ##STR1## wherein Pg and R are protecting groups and B is a nucleobase. The process uses protected nucleobases to form 2,2'-anhydro nucleosides having the formula ##STR2## which are hydrolyzed to 2'-hydroxy intermediates which are then oxidized to the desired 2'-keto compounds. The compounds and intermediates are useful as antiviral and antitumor agents and as intermediates to 2,2'-anhydro-1-(.beta.-D-arabinofuranosyl)cytosine (anhydro-ara-C) and 1-.beta.-D-arabinofuranosylcytosine (Ara-C).
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Barrett Brian P.
Boone David E.
Crane L. Eric
Eli Lilly and Company
Kight John
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