Molecular clone of a P58 receptor protein and uses thereof

Details Molecular clone of a P58 receptor protein and uses thereof Molecular clone of a P58 receptor protein and uses thereof

1994-05-24

1998-09-15

Teng, Sally P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 4352523, 43525411, 435325, 4353201, C12N 1512, C07K 14705

Patent

active

058080287

ABSTRACT:
The present invention provides a purified and isolated nucleic acid molecule encoding the p58 receptor protein. The present invention also provides vectors encoding this nucleic acid molecule, a host cell stably transformed or transfected with the vector, as well as the p58 receptor protein produced by this host cell. The present invention further provides methods for detecting nucleic acid encoding the p58 receptor as well as the p58 receptor protein in biological samples, methods for identifying a ligand capable of binding to the p58 receptor protein, and methods for screening for drugs capable of acting as agonists or antagonists to the p58 receptor protein. The present invention also provides the agonists and antagonists identified by the screening methods, as well as their use. Lastly, the present invention provides chimeric protein comprising the cytoplasmic region of a p58 receptor protein.

REFERENCES:
Lewin, Science, vol. 237, 1570, Sep. 25, 1987.
Reeck, Cell, vol. 50, 667, 1987.
Moretta, A. et al. "A Novel Surface Antigen Expressed By a Subset of Human CD3.sup.- CD16.sup.+ Natural Killer Cells" J. Exp. Med., 171:695-714 (1990).
Moretta, L. et al. "Human Natural Killer Cells; Origin, Clonality, Specificity, and Receptors" Advances in Immunology, 55:341-380 (1994).

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