Method for treating sensorineural hearing loss using glial cell

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514 2, 530350, 530399, C12N 1512, A61K 3818

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058376810

ABSTRACT:
The present invention relates generally to methods for preventing and/or treating injury or degeneration of cochlear hair cells and spiral ganglion neurons by administering glial cell line-derived neurotrophic factor (GDNF). The invention relates more specifically to methods for treating sensorineural hearing loss.

REFERENCES:
patent: 4518584 (1985-05-01), Mark et al.
patent: 5106627 (1992-04-01), Aebischer et al.
patent: 5653975 (1997-08-01), Baetge et al.
patent: 5658785 (1997-08-01), Johnson
Kelley (1997), `Cellular Commitment and Differentiation in the Cochlea: Potential Advances Using Gene Transfer` Audiol. Neurootol. 2:50-60.
Lindner et al. (1995), `Implantation of Encapsulated Catecholamine and GDNF-Producing Cells in Rats with Unilateral Dopamine Depletions and Parkinsonian Symptom` Exp. Neuro 132:62-76.
Choi-Lundberg et al. (1997), `Dopaminergic Neurons Protected from Degeneration by GDNF Gene Therapy` Science 275:838-841.
Raphael et al. (1996), `Adenoviral-mediated gene transfer into guinea pig cochlear cells in vivo` Neuro Ltrs 207:137-141.
Weiss et al. (1997), `Viral-Mediated Gene Transfer in the Cochlea` Int. J. Devl Neuroscience 4/5:577-583.
Lousteau (1987), `Increased Spiral Ganglion Cell Survival in Electrically Stimulated, Deafened Guinea Pig Cochleae` Laryngoscope 97:836-842.
Pfingst, et al. (1981), `Relation of Psychophysical Data to Histopathology in Monkeys with Cochlear Implants` Acta Otolaryngol 92:1-13.
Staecker, et al. (1996), `NT-3 and/or BDNF therapy prevents loss of auditory neurons following loss of hair cells` NeuroReport 7:889-894.
Staecker, et al. (1995) `NT-3 combined with CNTF promotes survival of neurons in modiolus-spiral ganglion explants`, Neuroreport, 6(11):1533-1537.
Zheng, et al. (1995) `Neurotrophin-4/5, Brain-Derived Neurotrophic Factor, and Neurotrophin-3 Promote Survival of Cultured Vestibular Ganglion Neurons and Protect Them against Neurotoxicity of Ototoxins`, J of Neurobiology, 18(3):330-340.
Aebischer et al. (1991), `Long-Term Cross-Species Brain Transplantation of a Polymer-Encapsulated Dopamine-Secreting Cell Line`, Exper. Neurol. 111:269-275.
Apfel et al. (1991), `Nerve Growth Factor Prevents Toxic Neuropathy in Mice`, Ann. Neurol. 29:87-90.
Cunningham and Wells (1989), `High-Resolution Epitope Mapping of hGH-Receptor Interactions by Alanine-Scanning Mutagenesis`, Science 244:1081-1085.
Ernfors et al. (1995), `Complementary Roses of BDNF and NT-3 in Vestibular Auditory Development`, Neuron 14:1153-1164.
Zheng et al. (1995), `Neurotrophin-4/5 Enhances Survival of Cultured Spiral Ganglion Neurons and Protects Them from Cisplatin Neurotoxicity`, J. Neurosci. 15(7):5079-5087.
Hefti (1986), `Nerve Growth Factor Promotes Survival of Septal Cholinergic Neurons After Fimbrial Transections`, Neurosci. 6:2155-2162.
Hefti (1994), `Neurotrophic Factor Therapy for Nervous System Degenerative Diseases`, J. Neurobiol. 25:1418-1435.
Hyman et al. (1991), `BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra`, Nature 350:230-232.
Knusel et al. (1992), `Brain-derived Neurotrophic Factor Administration Protects Basal Forebrain Cholinergic but Not Nigral Deopaminergic Neurons from Degenerative Changes after Axotomy in the Adult Rat Brain`, J. Neurosci. 12(11):4391-4402.
Koliatsos et al. (1993), `Evidence That Brain-Derived Neurotrophic Factor Is a Trophic Factor for Motor Neurons In Vivo`, Neuron 10:359-367.
Korsching (1993), `The Neurotrophic Factor Concept: A Reexamination`, J. Neurosci. 13(7):2739-2748.
Krieglstein et al. (1995), `TGF-.beta. superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP.sup.+ toxicity`, EMBO J. 14:736-742.
Lefebvre et al. (1994), `Neurotrophins affect survival and neuritogenesis by adult injured auditory neurons in vitro`, Neuro Report 5:865-868.
Lin et al. (1993), `GDNF: A Glial Cell Line-Derived Neurotrophic Factor for Midbrain Dopaminergic Neurons`, Science 260:1130-1132.
Malik et al. (1992), `Polyethylene Glycol (PEG)-modified Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) with Conserved Biological Activity`, Exp. Hematol. 20:1028-1035.
Matheson et al. (1995), `The In Vivo Responses of Neonatal Rat Dorsal Root Ganglion Neurons to Neurotrophins and GDNF`, Soc. Neurosci. Abstr. 21:544.
Mullins et al. (1990), `Ophthalmic Preparations`, Remington's Pharmaceutical Sciences, 18th Ed, Ch. 86:1581-1595.
Nadol (1993), `Hearing Loss`, New England J. of Medicine 329:1092-1102.
Oppenheim et al. (1995), `Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF`, Nature 373:344-346.
Pirvola et al. (1992), `Brain-derived neurotrophic factor and neurotrophin 3 mRNAs in the peripheral target fields of developing inner ear ganglia`, Proc. Natl. Acad. Sci. USA 89:9915-9919.
Poulsen et al. (1994), `TGF.beta.2 and TGF.beta.3 Are Potent Survival Factors for Midbrain Dopaminergic Neurons`, Neuron 13:1245-1252.
Schecterson et al. (1994), `Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear`, Hearing Res. 73:92-100.
Spoendlin (1984), `Primary Neurons and Synapses`, Ultrastructural Atlas of the Inner Ear Ch. 6:133-164.
Tresco et al. (1992), `Polymer Encapsulated Neurotransmitter Secreting Cells`, ASAIO 38:17-23.
Trupp et al. (1995), `Peripheral Expression and Biological Activities of GDNF, a New Neurotrophic Factor for Avian and Mammalian Peripheral Neurons`, J. Cell Biol. 130:137-148.
Wheeler et al. (1994), `Expression of BDNF and NT-3 mRNA in hair cells of the organ of Corti: Quantitative analysis in developing rats`, Hearing Res. 73:46-56.
Winn et al. (1991), `Behavioral Recovery following Inrastriatal Implantation of Microencapsulated PC12 Cells`, Exper. Neurol. 113:322-329.
Yan et al. (1992), `Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death`, Nature 360:753-755.
Yan et al. (1995), `In vivo neurotrophic effects of GDNF on Neonatal and adult facial motor neurons`, Nature 373:341-344.

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