Benzenesulphonamide derivatives

Details Benzenesulphonamide derivatives Benzenesulphonamide derivatives

1985-09-30

1987-08-04

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514248, 514253, 544235, 544293, 544363, 544383, 544391, 546160, A61K 31495, C07D40112

Patent

active

046846573

ABSTRACT:
Compounds having the formula ##STR1## wherein X.sub.1 and X.sub.2 are independently hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy; X.sub.3 is halogen or trifluoromethyl; one of A and E is CH and the other is CH or N and their pharmaceutically acceptable acid addition salts are useful as pharmaceuticals, in particular as anti-hypertensive agents. Novel 1-[4-(amino or nitro)benzenesulphonyl]-4-benzoylpiperazines are also disclosed as intermediate compounds.

REFERENCES:
patent: 3324129 (1967-06-01), Baget et al.
patent: 3935229 (1976-01-01), Giudicelli et al.
patent: 3992382 (1976-11-01), Coverdale et al.
patent: 4025629 (1977-05-01), Coverdale
patent: 4159331 (1979-06-01), McCall
patent: 4167567 (1979-09-01), McCall
Federation Proceedings, 42, 162-66 (1983).

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