Methods of producing vasodilation or antioxytocic activity

Details Methods of producing vasodilation or antioxytocic activity Methods of producing vasodilation or antioxytocic activity

1986-04-16

1987-08-04

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

A61K 3734

Patent

active

046846212

ABSTRACT:
Certain vasopressin-like peptides, which have an acyclic unit at position 1 and which have an .omega.-amino- or guanidinoalkyl substituent attached to the cysteine in the 6-position of the ring, have V.sub.1 -vasopressin and oxytocin antagonist activity. A species of this series of new compounds is [1-desaminopenicillamine-2-(O-ethyl-D-tyrosine)-8-(1,4-diaminobutane)-9-de sglycinamide]-vasopressin.

REFERENCES:
patent: 3941763 (1976-03-01), Sarantakis
patent: 4491577 (1985-01-01), Manning et al.
patent: 4604378 (1986-08-01), Callahan et al.
Rudinger, Peptide Hormones, Parson (ed), U. Park Press, Baltimore, 1976 pp. 1-7.
J. Lowbridge et al., J. Med. Chem. 22 565 (1979).
M. Manning et al., J. Med. Chem. 20 1228 (1977).
J. Bankowski et al., J. Med. Chem. 21 350 (1978).
H. Schulz et al., J. Med. Chem. 9 647 (1966).
Derwent Abstract of European Patent No. 112,809-A.
M. Manning et al., J. Med. Chem. 25 (1982).
Peptides: Chemistry, Structure and Biology (Ann Arbor Sciences) 737 (1975).

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