Topical treatment of glaucoma with 2-benzothiazolesulfonamide de

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514913, A61K 31425

Patent

active

049754491

ABSTRACT:
A topical composition for eye treatment of glaucoma, comprising a small but pharmaceutically effective amount of an analog of benzothiazole-2-sulfonamide. The most preferred compound is 6-chloro-benzothiazole-2-sulfonamide. The invention also relates to a method of topically treating glaucoma with eye drops to reduce intraocular pressure. Finally, disclosed is a method of synthesis of the preferred and highly effective benzothiazole-2-sulfonamide analogs, particularly the 6-chloro-benzothiazole-2-sulfonamide compound.

REFERENCES:
patent: 4386098 (1983-05-01), Woltersdorf et al.
Am. J. Vet. Res. 40(3), 334-345 (1979)--Gelatt et al.
AMA Drug Evaluation, 2nd ed.--1973--pp. 676; 678-679, 684-685-Publishing Science Group, Inc., Acton, Mass.
Investigative Ophthalmology 13(7), 479-483-Maren.
Drug Res. 25(5), 806-808 (1975)--de Feo et al.

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