CNQX and its analogs as therapeutics for degenerative neural dis

Details CNQX and its analogs as therapeutics for degenerative neural dis CNQX and its analogs as therapeutics for degenerative neural dis

1989-06-16

1990-12-04

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 31495

Patent

active

049754300

ABSTRACT:
Compounds of the formula ##STR1## wherein each X is independently nitro or cyano and wherein each Y is independently H, lower alkyl (1-4C), lower alkoxy (-4C), or CF.sub.3 have been shown to be successful antagonists of NMDA receptors. Accordingly, these compounds are useful in the treatment of neuronal conditions associated with stimulation of the NMDA receptor.

REFERENCES:
patent: 4812458 (1989-03-01), Honore et al.
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Blake et al., Neuro Sci. Let. (1988) 89:182-186.
Fletcher Brit. J. Pharmacol. (1988) pp. 586-587.
Drejer et al., Neuro Sci. Let. (1988) 87:104-108.
Birch et al., Eur. J. Pharmacol. (1988) 151:313-315.
Kemp et al., Proc. Natl. Acad. Sci. U.S.A. (1988) 85:6347-6350.
Kestler et al., Soc. Neuro. Sci. Abstr. (Abstr. (1987) 13:760.
Lester et al., Mol. Pharmacol. (1989) pp. 1-6.
Chem. Abst. 109:14034u (1988).

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